Targeting the Sonic Hedgehog Pathway in Keratocystic Odontogenic Tumor
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چکیده
منابع مشابه
Targeting the sonic hedgehog pathway in keratocystic odontogenic tumor.
Keratocystic odontogenic tumors (KCOT) may occur sporadically or associated with the nevoid basal cell carcinoma syndrome. It is a benign aggressive tumor of odontogenic epithelial origin with a high rate of recurrence. A primary human keratocystic odontogenic tumor cell population, KCOT-1, has been established from a tumor explant culture. The KCOT-1 cells were characterized by growth rate, ge...
متن کاملRecurrence of keratocystic odontogenic tumor: clinicopathological features and immunohistochemical study of the Hedgehog signaling pathway.
AIMS Critical factors responsible for the recurrence of keratocystic odontogenic tumor (KCOT) were examined. METHODS The clinicopathological features were retrospectively studied in 74 patients with 75 sporadic KCOTs. From the 75 KCOTs, 23 were examined for the expression of Sonic Hedgehog (SHH), Patched and Smoothened (SMO) by immunohistochemistry. RESULTS Recurrence in multilocular lesion...
متن کاملPathogenesis of Keratocystic Odontogenic Tumor-a Review
PATHOGENESIS OF KERATOCYSTIC ODONTOGENIC TUMOR-A REVIEW Sunayana Tandon, 1 Khushboo Phull, 2 Piyush Tandon Reader, 1 Senior Lecturer, 2 Reader, 1. Department of Oral & Maxillofacial Surgery, Teerthanker Mahaveer Dental College & Research Center, Moradabad, Uttar Pradesh 2. Department of Oral Pathology & Microbiology, Teerthanker Mahaveer Dental College & Research Center, Moradabad, Uttar Prades...
متن کاملGiant keratocystic odontogenic tumor: a challenging diagnosis
The keratocystic odontogenic tumor, although a benign lesion, is peculiarly aggressive with a high recurrence rate. Its involvement with the maxillary antrum is atypical. We report the unusual case of a 20-year-old male patient with an extensive antral tumor associated with an impacted third molar, which was initially misdiagnosed as a dentigerous cyst. Clinical, radiographic, and histopatholog...
متن کاملExploring the concept of “inflammatory angiogenesis” in keratocystic odontogenic tumor
OBJECTIVE The aim of the present study was to investigate the role of inflammation in angiogenesis of keratocystic odontogenic tumor (KCOT). STUDY DESIGN Twenty inflamed and 20 non-inflamed KCOTs were selected based on quantitative scoring of inflammation which was also applied on 20 radicular cysts. Microvessel density was assessed in all samples using CD34 antibody and angiogenesis was comp...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.367680